Endocrine Abstracts

Introduction: Testosterone <5nmol/l is commonly seen in conditions such as PCOS however when testosterone is >5nmol/l, concerns start to rise about more sinister causes. Here, we present a case of a female who was referred to clinic with testosterone >5mmol/lCase: A 32 year old presented to the GP with a heavier than usual menstrual period. For an unknown reason, the GP checked testosterone, which came back a...

Design: Macroprolactinemia may influence the interpretation of serum prolactin levels – a recognised phenomenon since 19781. The degree of macroprolactinaemia over time is less well described. We determined how macroprolactin status (based on polyethylene glycol (PEG) precipitation varied by analysing serial measurements in hyperprolactinaemic individuals over nine years.Patients and Measurements: Results from 1810 individuals were includ...

Background: Adrenal insufficiency (AI) requires life-long glucocorticoid substitution therapy (1), and bears significant risks of infection, cardiovascular (CV) & metabolic disease burden. Historically Hydrocortisone (HC) has been the mainstay of treatment. Prednisolone is a once-daily alternative due to a longer half-life (up to 3.2 hrs). Currently, there is no discernible evidence supporting the superiority of either medication (2).Objective: To ex...

Background: Inherited metabolic disorders (IMDs) are a group of heterogenous genetic disorders resulting in substrate accumulation, energy deficiency or complex molecular defects due to the failure of specific molecules to act as enzymes, cofactors, transporters, or receptors in specific metabolic pathways. The pathophysiological changes seen in IMDs sometimes impact on the endocrine system. We here describe our experience at one UK centre where patients are seen jointly by an...

Background: Primary adrenal insufficiency or Addison’s disease (AD) is characterized by glucocorticoid and mineralocorticoid deficiency due to lesion of the adrenal glands through different mechanisms (1). Addison’s disease is a risk factor for adverse maternal and neonatal outcomes. Close monitoring is required for these patients during the intrapartum and postpartum periods.(2)Objective: Retrospective evaluation of the management of Addison&#...

Background: Omission of steroids and unsafe steroid prescription in Adrenal insufficiency (AI) patients during intercurrent illness or surgery is unfortunately common, and can lead to adrenal crisis and potentially death. Anna Mitchell et al, New Castle-upon-Tyne have demonstrated potential use of electronic automation with steroid alerts to minimise human error for ensuring patient safety.Objectives: 1. Similar use of artificial intelligence wa...

Background: Radiotherapy is a third line treatment in Acromegaly. Pituitary radiotherapy (RT) is known to have cardiovascular complications (MI/IHD, CCF & CVA) due to radiation effects on normal pituitary and surrounding structures over and above the excess Growth hormone risk on metabolism (1).Objective: To compare RT vs non-RT treated Acromegaly cohorts’ cardiovascular (CV) outcomes in unselected consecutive Acromegaly patients.<p class="a...

Introduction: Obesity is a pathological condition characterized by a low-grade systemic inflammatory state that predisposes to the onset of some diseases, such as hypertension, diabetes, and hyperlipidemia. Also, obesity can impact bone metabolism, but its effects are controversial.Aims: This observational study aimed to evaluate and correlate the bone mass with the lipidic profile, adipocytokines, glucose metabolism, hepatic function and purine metaboli...

Introduction: Glioblastoma, an aggressive intracranial tumour usually is a solitary lesion and not commonly located in the sella turcica. Panhypopituitarism due to multicentric glioblastoma can present with a challenging clinical picture masking or delaying the underlying diagnosis. Case presentation: 58 year old female presented with marked behavioural change, reduced appetite, nausea, polyuria & increased thirst over 4-6 weeks precipitating into an...

Background: Adrenal crisis is a life threatening emergency with an incidence of 5–10 adrenal crises/100 patient-years with mortality around 0.5/100 patient-years.Objective: Audit of inpatient adrenal crisis management was undertaken in line with Society for Endocrinology (SFE) guidance 2016 (Trust audit No:9763).Methods: Retrospective evaluation of electronic and paper case records of 2 years (January 2017–December 2018)....